https://pl.wikipedia.org/wiki/Historia_aspiryny
The history of aspirin, acetylsalicylic acid (ASA) and its medical use dates back to ancient times, although the substance has been produced and sold in its pure form since 1899. Information about medicines made from willow bark and other plants rich in salicylates was found as early as the 2nd century BC on papyrus written in the time of the Egyptian pharaohs, around 400 BC. Hippocrates wrote about the use of herbal infusions containing salicylates to reduce fever, salicylates were also used in oriental medicine in antiquity and the Middle Ages. The healing properties of willow bark extract, such as antipyretic, analgesic and anti-inflammatory effects, were appreciated in the mid-18th century.
Lewis and Clark claimed to have used infusions of willow bark as an antipyretic among the participants of their famous expedition of 1803-1806. Already at the beginning of the 19th century, pharmacists tried and prescribed various substances that resemble salicylic acid, the active component of willow bark extract. In 1853, chemist Charles Frédéric Gerhardt first prepared acetylsalicylic acid by mixing acetylsalicylic acid with sodium salicylate; In the second half of the 19th century, other chemists established the chemical structure of the compound and developed a more effective and efficient method of synthesis. In 1897, scientists from the pharmaceutical and chemical company Bayer began research on acetylsalicylic acid as a less irritating substitute for common salicylate-containing drugs. In 1899, the drug was named Aspirin and Bayer sold it worldwide. The word aspirin was a brand name created by Bayer, not the generic name of the drug itself, but Bayer's trademark rights have been sold or lost in many countries. The rise of aspirin in the first half of the 20th century was due to its effectiveness during the Spanish flu pandemic of 1918-1919. The profitability of aspirin production has led to fierce competition and proliferation of similar products and brands. Some of the deaths recorded during the 1918 pandemic were probably related to aspirin poisoning.
https://pl.wikipedia.org/wiki/Historia_aspiryny
https://en.wikipedia.org/wiki/History_of_aspirin
The popularity of aspirin declined after the invention of paracetamol in
1956 and ibuprofen in 1962 in the 1960s and 1970s. In the 1980s, researchers like John Vane discovered the underlying mechanisms and effects of aspirin. Clinical trials conducted from the 1960s to the 1980s. In the 20th century, aspirin was shown to be effective as an anticoagulant. Sales of aspirin have rebounded in the last decades of the 20th century and remain at a high level; the drug is often used for the prevention of heart attacks and strokes.
